Dr Seerapani Gopaluni
MBBS, MRCP (Nephrology), CCT (UK), PhD in Autoimmune diseases (University of Cambridge)
Dr Seerapani Gopaluni is one of the best nephrologists in Hyderabad, currently working in the Citizens Hospital as a Consultant. He has an overall experience of 12 years and he worked in the UK at some of the world’s renowned Nephrology and Transplant Centres such as Leeds, Oxford & Cambridge.
He is an expert kidney doctor in Hyderabad, and his areas of expertise include renal transplantation and managing auto-immune conditions such as lupus and vasculitis. His areas of special interest include assessing patients’ suitability for renal transplantation, pre and post-operative patient management, immunosuppression and dealing with graft dysfunction. Further, he has a keen interest in the diagnosis and management of glomerulonephritides and autoimmune diseases. He pursued PhD from Cambridge (UK), one of the top Universities in the world, where he studied the role of the immune system in auto-immune conditions. He also worked in internationally acclaimed lupus and vasculitis centre (Addenbrooke’s Hospital) under the mentorship of Prof David Jayne. During his time in the UK, he developed expertise in the use of cytotoxic and biologic (monoclonal antibodies) drugs in the management of transplant and nephrology patients. He is one of the best kidney disease treatment doctor in Hyderabad and is adept at dealing with various clinical aspects of acute kidney injury, haemodialysis, and peritoneal dialysis. He is also passionate about teaching and has been a clinical tutor (Lincoln college, Oxford University) delivering bed-side teaching to medical students.
- PhD (Autoimmune diseases) – University of Cambridge, 2021
- Nephrology Specialist Training (CCT) – Oxford, Aug 2014
- General Internal Medicine Specialist Training (CCT) – Oxford, Aug 2014
- MRCP (Nephrology) – UK, Mar 2013
- MRCP – UK, Mar 2008
- M.B.B.S – India, Jun 2003
Clinical experience:
- Worked in three internationally renowned transplant centres (Leeds, Oxford and Cambridge)
- Worked in an acclaimed lupus and vasculitis centre (Addenbrooke’s Hospital) for over 5 years
- General Medicine and Nephrology training in Oxford
- Experienced in the management of chronic haemodialysis and peritoneal dialysis patients.
- Extensive clinical experience in the diagnosis and management of acute medical emergencies, chronic medical conditions and patients with primary and refractory vasculitides.
Practical skills:
- Central venous access: Jugular & Femoral
- Tunnelled permanent lines
- Ultrasound guided Transplant Renal biopsy
- Native Renal biopsy
Research Experience:
Dr Gopaluni pursued PhD from Cambridge, where he studied the role of T cells in the pathogenesis of an auto-immune disease called ANCA associated vasculitis. Further, he has extensive experience in clinical trials design (co-investigator of £1.9 million NIHR grant), clinical trial execution, statistical analysis of data, advanced bio-informatics to analyse bulk and single cell transcriptomics data, flow-cytometry to answer biologically important questions that would make a difference to patient’s care. He uses his knowledge in advanced bio-informatics to strive for better patient outcomes. He is proficient in using R, a computer language for data manipulation, statistics and graphics.
RESEARCH GRANTS
- £1.98 million NIHR grant co-applicant (BIOVAS) 2019
- $1000 bursary to attend Vasculitis 2019 in Philadelphia 2019
- £1000 bursary to attend ANCA 2017 workshop in Tokyo 2017
- £45,000 Vasculitis UK grant co-applicant 2017
- £250,000 Experimental Medicine Training Initiative fellowship 2016 (University of Cambridge & Glaxo-Smith Kline collaboration).
Clinical and academic
- Teacher of the month May 2012 for teaching medical students at John Radcliffe Hospitals, Oxford
- Distinction Poster at ATC Boston May 2009 for “Factors effecting erectile dysfunction in renal transplant patients”.
- Distinction in Anatomy University examination.
- Distinction and Gold medal in ENT University examination.
- Distinction in Ophthalmology University examination.
- First Division in MBBS final examinations
INVITED TALKS
- Biologics in vasculitides: British society of rheumatology, Birmingham 2019
- Clinical trials in vasculitis. Vasculitis UK, Annual General Meeting 2018
ORAL PRESENTATIONS
- Peripheral T helper cells may play a role in the pathogenesis of ANCA associated vasculitis, October 14th, 2020, Renal Association.
- ALEmtuzumab for Relapsing and Refractory Primary Systemic Vasculitis – A Trial of Efficacy and Safety (ALEVIATE): A Randomised Open Label Phase II Clinical Trial, Vasculitis conference, Philadelphia, 2019.
- UK & Ireland Vasculitis Society meeting, London, ALEVIATE trial, 2018
- European Vasculitis Society meeting: Clinical trials in vasculitis, Florence, 2018
- TARGET consortium (Treatment According to Response in Giant cEll arteritis): BIOVAS, Leeds, UK, 2018
- Department of Medicine, Cambridge, Grand rounds presentation, 2018
- UKIVAS meeting: BIOVAS design, Cork, Ireland, 2017
- UK Glomerulonephritis Consortium, Low dose steroids vs standard dose steroids in ANCA associated vasculitis, Peterborough, UK, 2017
- European Vasculitis Society meeting: Early disease response as predictors of long term outcomes in ANCA associated vasculitis, 2017
- European Vasculitis Society meeting, Tokyo, Japan: BIOVAS & COMBIVAS trial designs, 2017
- BIOVAS investigators meeting, London 2016
- Patient and public involvement exercise, BIOVAS, Cambridge 2016
- Wagner J, Harrison E. M, Martinez M, Pero D, Blane B, Mayer G, Leierer J, Gopaluni S, Holmes M A, Parkhill J, Peacock S J, Jayne D R, Kronbichler A (2019). The composition and functional protein subsystems of the human nasal microbiome in granulomatosis with polyangiitis : a pilot study. Microbiome (2019) 7:137
https://doi.org/10.1186/s40168-019-0753-z - Evaluation of PR3-ANCA Status After Rituximab for ANCA-Associated Vasculitis. McClure ME, Wason J, Gopaluni S, Tieu J, Smith RM, Jayne DR, Jones RB. J Clin Rheumatol. 2019 Mar 20. doi: 10.1097/RHU.0000000000001030
- A novel glucocorticoid-free maintenance regimen for anti-neutrophil cytoplasm antibody-associated vasculitis. Pepper RJ, McAdoo SP, Moran SM, Kelly D, Scott J, Hamour S, Burns A, Griffith M, Galliford J, Levy JB, Cairns TD, Gopaluni S, Jones RB, Jayne D, Little MA, Pusey CD, Salama AD. Rheumatology (Oxford). 2019 Feb 1;58(2):260-268. doi: 10.1093/rheumatology/key288.
- Effect of Disease Activity at Three and Six Months After Diagnosis on Long-Term Outcomes in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Gopaluni S, Flossmann O, Little MA, O’Hara P, Bekker P, Jayne D; European Vasculitis Society. Arthritis Rheumatol. 2019 May;71(5):784-791. doi: 10.1002/art.40776. Epub 2019 Mar 28.
- B cell therapy in ANCA-associated vasculitis: current and emerging treatment options. McClure M, Gopaluni S, Jayne D, Jones R. Nat Rev Rheumatol. 2018 Oct;14(10):580- 591. doi: 10.1038/s41584-018-0065-x. Epub 2018 Aug 14. Review.
- A retrospective study comparing the phenotype and outcomes of patients with polyarteritis nodosa between UK and Turkish cohorts. Karadag O, Erden A, Bilginer Y, Gopaluni S, Sari A, Armagan B, Ertenli I, Ozen S, Jayne D. Rheumatol Int. 2018 Oct;38(10):1833-1840. doi: 10.1007/s00296-018-4122-1. Epub 2018 Aug 11.
- Trimethoprim-sulfamethoxazole prophylaxis prevents severe/life-threatening infections following rituximab in antineutrophil cytoplasm antibody-associated vasculitis. Kronbichler A, Kerschbaum J, Gopaluni S, Tieu J, Alberici F, Jones RB, Smith RM, Jayne DRW. Ann Rheum Dis. 2018 Oct;77(10):1440-1447. doi: 10.1136/annrheumdis2017-212861. Epub 2018 Jun 27.
- McAdoo, S. P., Medjeral-Thomas, N., Gopaluni, S., Tanna, A., Mansfield, N., Galliford, J., Griffith, M., et al. (2018). Long-term follow-up of a combined rituximab and cyclophosphamide regimen in renal anti-neutrophil cytoplasm antibody-associated vasculitis.. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association, 2018, 33 (5), 899.
https://doi.org/10.1093/ndt/gfy075 - Gopaluni, S., Smith, R. M., Lewin, M., McAlear, C. A., Mynard, K., Jones, R. B., Jayne, D. R. W. (2017). Rituximab versus azathioprine as therapy for maintenance of remission for anti-neutrophil cytoplasm antibody-associated vasculitis (RITAZAREM): study protocol for a randomized controlled trial. Trials, 18(1), 112.
http://doi.org/10.1186/s13063-017-1857-z - Gopaluni, S., Sherif, M., & Ahmadouk, N. A. 2016. Cochrane systematic review: Interventions for chronic kidney disease-associated restless legs syndrome. Cochrane Database of Systematic Reviews. doi: 10.1002/ 14651858. CD010690.pub2
- Gopaluni, S., & Jayne, D. (2016). Clinical Trials in Vasculitis. Current Treatment Options in Rheumatology, 2(2), 161–177. doi:10.1007/s40674-016-0045-8
- Gopaluni, S. and Jayne, D. 2015. Immune Vasculitis. eLS. 1–8. DOI: 10.1002/9780470015902.a0002150.pub3
- Hindocha, S., Gopaluni, S., Collins, G. P., & Shenbagaraman, P. (2015). Focal segmental glomerulosclerosis in a patient with mantle cell lymphoma. BMJ Case Reports, 2015. doi:10.1136/bcr-2015-211765
- Gopaluni, S., Gibson, M., & Mohteshamzadeh, M. (2014). An unusual case of familial cystic kidney disease. Clinical Kidney Journal, 7(5), 484–485. doi:10.1093/ckj/sfu075
- Gopaluni, S., Sherif, M., & Ahmadouk, N. A. (2013). Protocol- Interventions for chronic kidney disease-associated restless legs syndrome. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.CD010690.
- Ball MJ, Gopaluni S, Mathavakkannan S, Brian M, and Farrington K. An immunocompromised dialysis patient with skin and bone lesions. NDT Plus 2010 0: sfq010v1-sfq010; doi:10.1093/ndtplus/sfq010
- S Gopaluni, S Lines, AJP Lewington, Acute kidney injury in the critically ill patient, Current Anaesthesia & Critical Care 21 (2), 60-64, April 2010
- Seerapani Gopaluni, Aadil Shaukat, Martin Gray, Roshni Gokhale and M Al-Bustami Premature myocardial infarction presenting with acuacutete pulmonary embolism: a case report. Journal of Medical Case Reports 2009, 3:8786